Trifluoroacetic acid (TFA) is a strong fluorinated organic acid used as a reagent in organic synthesis and analytical chemistry workflows.
Trifluoroacetic Acid, catalogue No. T6508, is a high-purity organofluorine reagent supplied by Sigma-Aldrich / Merck under the ReagentPlus® quality designation with a 99% assay. Also known as TFA, this compound is a strong carboxylic acid and a clear liquid reagent widely used in organic synthesis, analytical chemistry and method development. Its strong acidic properties and high volatility make it suitable for acid-catalyzed transformations, deprotection of protecting groups and other laboratory protocols requiring a strong acid.
Advantages
- High assay (99%) ensures consistent reactivity in laboratory applications.
- ReagentPlus® quality suitable for general research and synthetic use.
- Strong acidity and high volatility facilitate ease of removal after reactions.
- Compatible with a range of organic synthesis and analytical workflows.
- Liquid form allows precise dispensing and solution preparation.
Technical specifications
| Product name | Trifluoroacetic Acid, ReagentPlus® 99% |
| Catalogue number | T6508 |
| Brand | Sigma-Aldrich / Merck |
| Chemical formula | CF3COOH |
| CAS number | 76-05-1 |
| Molecular weight | 114.02 g/mol |
| Assay | 99% ReagentPlus® |
| Form | Liquid |
| Quality level | 200 |
| Physical properties | Clear liquid |
| Density | 1.489 g/mL at 20 °C |
| Boiling point | 72.4 °C (lit.) |
| pH | ~1 (10 g/L) |
| Solubility | Soluble in ethanol and organic solvents |
| Storage conditions | 15–25 °C, tightly closed |
| Brand | Merck |
